Dr. Chen Dong

Dr. Chen Dong

Shanghai Immune Therapy Institute, Shanghai Jiao Tong University / Institute for Immunology and School of Medicine, Tsinghua University / New Cornerstone Science Laboratory
BioGRAPHY

Dr. Dong is Professor at Shanghai Jiao Tong University School of Medicine and Director for the Shanghai Immune Therapy Institute, as well as a principal investigator at the Institute for Immunology at Tsinghua University. Dr. Dong served as a Professor of Immunology and the Director of the Center for inflammation and Cancer at the University of Texas MD Anderson Cancer Center before his move to China, and also was Dean of Tsinghua University School of Medicine in 2016-2020.

Dr. Dong’s research is to understand the molecular mechanisms whereby immune and inflammatory responses are normally regulated, and to apply this knowledge to the understanding and treatment of infection, autoimmunity and allergy disorders as well as cancer. The work from Dr. Dong’s group has led to the discoveries of Th17 and T follicular helper (Tfh) cell subsets in the immune system and elucidation of their biological and pathological functions.

Dr. Dong has over 200 publications and was rated highly cited researcher for seven times. The honors he has received include the 2009 American Association of Immunologists-BD Bioscience Investigator Award and 2019 International Cytokine and Interferon Society Biolegend-William E. Paul Award. He is a member of the Chinese Academy of Sciences and a fellow of the American Association for the advancement of Science and the Chinese Academy of Medicine. He is currently co-editor-in-chief for Current Opinion in Immunology and hLife, Editor-in-chief for Frontiers in Immunology- T Cell Biology, Executive Associate Editor for China Sciences- Life Sciences, Associate Editor for Advances in Immunology, and an Editor for Annual Review of Immunology and Immunity, and a Scientific Advisor for Med.

Speaker's Schedule

July 9, 2023
16:00 - 16:25
Molecular Control of T Cell Function in Cancer
Dr. Chen Dong
Shanghai Immune Therapy Institute, Shanghai Jiao Tong University / Institute for Immunology and School of Medicine, Tsinghua University / New Cornerstone Science Laboratory
T cells differentiate into effector cells during pathogen infections, but become dysfunctional by the tumor microenvironments. T cell function is tightly regulated by a combinational co-stimulatory signal; costimulation is needed for T cell differentiation into effector T cells, whereas dominance of co-inhibition results in T cell dysfunction. During the meeting, I will discuss on how T cells are regulated by co-inhibition molecules in their dysfunction induction, and the underlying molecular mechanisms. Moreover, I will discuss on cytokines and transcription factors that determine the function of intra-tumor CD8+ T cells. These knowledges may benefit our understanding on tumor immunity and find new targets in tumor immunotherapy.
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