Prof. Hailan Hu

Dr. Hailan Hu

School of Brain Science and Brain Medicine, Zhejiang University
BioGRAPHY

Dr. Hailan Hu is the Professor and Director of the School of Brain Sciences and Brain Medicine at Zhejiang University. Dr. Hu graduated from Beijing University with a B.S. degree in Biochemistry (1996). She pursued her Ph.D. degree in neuroscience at University of California at Berkeley with Prof. Corey Goodman. After completing PhD (2002), she conducted postdoctoral research with Dr. Julius Zhu at University of Virginia (2003-2004), and Dr. Roberto Malinow at Cold Spring Harbor Laboratory (2004-2008). Before joining Zhejiang University, Dr. Hu was a principal investigator at the Institute of Neuroscience, Chinese Academy of Sciences (2008-2015). Her laboratory seeks to understand how emotional and social behaviors are encoded and regulated in the brain. Dr. Hu is a recipient of the CAS Excellent Mentorship Award, the IBRO Kemali International Neuroscience Award and UNESCO-L’Oreal Women Scientist Award.

Speaker's Schedule

July 9, 2023
08:55 - 09:20
Neural Mechanisms Underlying Ketamine's Mode of Action
Dr. Hailan Hu
School of Brain Science and Brain Medicine, Zhejiang University
Ketamine, the NMDAR antagonist, has revolutionized depression treatment because of its robust, rapid and sustained antidepressant effects. Recently, it was discovered that ketamine inhibits the NMDAR-dependent burst firing of the brain’s anti-reward center, the lateral habenula (LHb). By silencing the LHb bursts, ketamine can disinhibit the aminergic reward circuits downstream of LHb to exert its rapid antidepressant effects.
However, at least three key questions have remained unaddressed. Firstly, does blockade of LHb burst firing contribute to ketamine’s sustained antidepressant effects? Secondly, given that NMDARs are ubiquitously expressed, which specific brain region is the direct target of ketamine? Thirdly, will a drug targeting the same cellular/circuit mechanism of ketamine have similar antidepressant effects? In this talk, I will present our ongoing efforts in addressing these three urgent questions, which will hopefully illuminate a more unified theory on ketamine’s mode of action and inspire new treatment strategies for depression.
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