Dr. Xin-Yuan Fu

Professor, Director, Laboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University / GenEros BioPharma, Hangzhou, China
BioGRAPHY

Dr. Fu currently is a Senior Chair Professor of West China Hospital, and

Dean, Institution of Immunology and Inflammation, Sichuan University, China

Received his PhD in molecular biology at Columbia University in 1988 (Mentor: James Manley)

Postdoctoral training at Rockefeller University with James Darnell (1988-1991)

Assistant Professor at Mt Sinai School of Medicine NY (1992-1994)

Assistant & Associate Professor at Yale University (1994-2003)

Full Professor at Indiana University (2004-2015).

Founding director of Tsinghua Institute of Genome Research of Tsinghua University, China (2000-2006).

Head (2008-2011) and Professor (2008-2019) of Department of Biochemistry of National University of Singapore

Senior Principal Investigator, Singapore Cancer Science Institute, Singapore (2008 – 2019)

Dr Fu and his colleagues discovered the STAT gene family and the JAK-STAT signaling Pathway (Fu and Darnell et al, PNAS 89:7840-7843, 1992; Fu, Cell, 70:323-335, 1992). He has made a number of seminal discoveries in molecular mechanisms of mammalian development, immunity and diseases in the past 30 years. Particularly, since Dr Fu's original discovery, there are about 100,000 publications on the JAK-STAT pathway, and over 12 FDA approved drugs against the JAK-STAT. In the past 12 years,

Dr Fu’s laboratory has focused on STAT's role in regulation of inflammation, development and cancer.

GenEros BioPharma is a cutting-edge drug discovery company founded by Dr Xin-Yuan Fu in 2015. GenEros pipelines focus on precision of medicine across inflammatory diseases and cancer. The company now have four clinical trials worldwide aiming at creating FIC or BIC small molecular drugs for unmet medical needs in major inflammatory diseases and late stage cancers.

Speaker's Schedule

July 9, 2023
14:00 - 14:25
From JAK-STAT to Mechanisms of Inflammation, Immunity and Medicine
Dr. Xin-Yuan Fu
Professor, Director, Laboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University / GenEros BioPharma, Hangzhou, China
The first two STAT proteins and their activators and JAK (Just Another Kinase) were discovered over 30 years ago as Transcription Activator of p91 (STAT1) and p113 (STAT2) activated by interferon-alpha. The molecular cloning of genes encoding for p91 and p113 revealed the STAT gene family. Finding a SH2 domain in each of STAT proteins indicated STAT proteins are not only transcription factors but also serve as Signal Transducers. Thus the name of STAT (Signal Transducer and Activator of Transcription) was given. Over past 30 years there are over 100,000 publications in the JAK-STAT field, generating an important impact on life sciences. Here we demonstrate STAT5 is key players in regulation of immunity and inflammation. In particular, we revealed a distinct T helper cell subset that produces GM-CSF (Th-GM) and other related cytokines for inflammation. We further developed applications and approaches modulating the Th-GM pathway in drug discovery for inflammatory diseases.
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